{"id":3842,"date":"2021-12-02T08:01:41","date_gmt":"2021-12-02T07:01:41","guid":{"rendered":"https:\/\/aa-pnh.pe-dev.de\/glossar\/antithymocyte-globulin\/"},"modified":"2021-12-02T08:01:41","modified_gmt":"2021-12-02T07:01:41","slug":"antithymocyte-globulin","status":"publish","type":"glossary","link":"https:\/\/aa-pnh.org\/en\/glossar\/antithymocyte-globulin\/","title":{"rendered":"Antithymocyte globulin"},"content":{"rendered":"<p><a class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;ATG&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;ATG; immunosuppressive mixture of antibodies obtained from rabbits or horses. It reduces the number of lymphocytes (lymphocytopenia), mainly by suppressing circulating T-lymphocytes. It is used for instance to treat aplastic anaemia and for the prophylaxis and therapy of GvHD in the context of(...)&lt;\/div&gt;\"  href=\"https:\/\/aa-pnh.org\/en\/glossar\/atg\/\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]'  tabindex='0' role='link'>ATG<\/a>; <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;immunosuppressive&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Suppression of the immune system&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/immunosuppressive\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">immunosuppressive<\/a> mixture of antibodies obtained from rabbits or horses. It reduces the number of <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;lymphocytes&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Subgroup of white blood cells that play a role in the defence against diseases and foreign substances&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/lymphocytes\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">lymphocytes<\/a> (lympho<a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;cytopenia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Reduction in the number of cells in the blood, e.g. erythro-, leuko-, granulo-, lympho- or thrombocytopenia&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/cytopenia\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">cytopenia<\/a>), mainly by suppressing circulating T-<a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;lymphocytes&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Subgroup of white blood cells that play a role in the defence against diseases and foreign substances&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/lymphocytes\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">lymphocytes<\/a>. It is used for instance to treat <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;aplastic&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Condition of the non-functional bone marrow that cannot develop blood cells&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/aplastic\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">aplastic<\/a> anaemia and for the <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;prophylaxis&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Prevention or precaution&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/prophylaxis\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">prophylaxis<\/a> and therapy of <a class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;GvHD&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;GvHD; graft versus recipient response. The donor&amp;#039;s immune system transplanted with a foreign donation (e.g. stem cells) can recognise the recipient&amp;#039;s body cells as foreign and attack them. A distinction is made between acute GvHD (grades 1-4) and chronic GvHD (limited and extensive form). The(...)&lt;\/div&gt;\"  href=\"https:\/\/aa-pnh.org\/en\/glossar\/gvhd\/\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]'  tabindex='0' role='link'>GvHD<\/a> in the context of stem cell transplantation.     <\/p>\n","protected":false},"excerpt":{"rendered":"<p><a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;ATG&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;ATG; immunosuppressive mixture of antibodies obtained from rabbits or horses. It reduces the number of lymphocytes (lymphocytopenia), mainly by suppressing circulating T-lymphocytes. It is used for instance to treat aplastic anaemia and for the prophylaxis and therapy of GvHD in the context of(...)&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/atg\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">ATG<\/a>; <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;immunosuppressive&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Suppression of the immune system&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/immunosuppressive\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">immunosuppressive<\/a> mixture of antibodies obtained from rabbits or horses. It reduces the number of <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;lymphocytes&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Subgroup of white blood cells that play a role in the defence against diseases and foreign substances&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/lymphocytes\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">lymphocytes<\/a> (lympho<a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;cytopenia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Reduction in the number of cells in the blood, e.g. erythro-, leuko-, granulo-, lympho- or thrombocytopenia&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/cytopenia\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">cytopenia<\/a>), mainly by suppressing circulating T-<a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;lymphocytes&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Subgroup of white blood cells that play a role in the defence against diseases and foreign substances&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/lymphocytes\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">lymphocytes<\/a>. It is used for instance to treat <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;aplastic&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Condition of the non-functional bone marrow that cannot develop blood cells&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/aplastic\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">aplastic<\/a> anaemia and for the <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;prophylaxis&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Prevention or precaution&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/prophylaxis\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">prophylaxis<\/a> and therapy of <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;GvHD&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;GvHD; graft versus recipient response. The donor&amp;#039;s immune system transplanted with a foreign donation (e.g. stem cells) can recognise the recipient&amp;#039;s body cells as foreign and attack them. A distinction is made between acute GvHD (grades 1-4) and chronic GvHD (limited and extensive form). The(...)&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/gvhd\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">GvHD<\/a> in the context of stem cell&hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"menu_order":0,"template":"","meta":{"footnotes":""},"class_list":["post-3842","glossary","type-glossary","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/glossary\/3842","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/glossary"}],"about":[{"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/types\/glossary"}],"author":[{"embeddable":true,"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/users\/3"}],"version-history":[{"count":0,"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/glossary\/3842\/revisions"}],"wp:attachment":[{"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/media?parent=3842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}