{"id":3912,"date":"2021-12-02T08:49:12","date_gmt":"2021-12-02T07:49:12","guid":{"rendered":"https:\/\/aa-pnh.pe-dev.de\/glossar\/gvhd\/"},"modified":"2021-12-02T08:49:19","modified_gmt":"2021-12-02T07:49:19","slug":"gvhd","status":"publish","type":"glossary","link":"https:\/\/aa-pnh.org\/en\/glossar\/gvhd\/","title":{"rendered":"GvHD"},"content":{"rendered":"<p><a class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;GvHD&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;GvHD; graft versus recipient response. The donor&amp;#039;s immune system transplanted with a foreign donation (e.g. stem cells) can recognise the recipient&amp;#039;s body cells as foreign and attack them. A distinction is made between acute GvHD (grades 1-4) and chronic GvHD (limited and extensive form). The(...)&lt;\/div&gt;\"  href=\"https:\/\/aa-pnh.org\/en\/glossar\/gvhd\/\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]'  tabindex='0' role='link'>GvHD<\/a>; graft versus recipient response. The donor&rsquo;s <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;immune system&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Defence system; system that enables the body to fight off infections and to distinguish between its own and foreign tissues. In humans, the immune system consists of specialised proteins (antibodies), immune cells (white blood cells) and immune organs. It is responsible for our body&amp;#039;s defences(...)&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/immune-system\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">immune system<\/a> transplanted with a foreign donation (e.g. stem cells) can recognise the recipient&rsquo;s body cells as foreign and attack them. A distinction is made between <a class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;acute&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Sudden onset, rapidly progressing&lt;\/div&gt;\"  href=\"https:\/\/aa-pnh.org\/en\/glossar\/acute\/\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]'  tabindex='0' role='link'>acute<\/a> <a class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;GvHD&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;GvHD; graft versus recipient response. The donor&amp;#039;s immune system transplanted with a foreign donation (e.g. stem cells) can recognise the recipient&amp;#039;s body cells as foreign and attack them. A distinction is made between acute GvHD (grades 1-4) and chronic GvHD (limited and extensive form). The(...)&lt;\/div&gt;\"  href=\"https:\/\/aa-pnh.org\/en\/glossar\/gvhd\/\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]'  tabindex='0' role='link'>GvHD<\/a> (grades 1-4) and <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;chronic&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Over a long period of time and persistent&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/chronic\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">chronic<\/a> <a class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;GvHD&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;GvHD; graft versus recipient response. The donor&amp;#039;s immune system transplanted with a foreign donation (e.g. stem cells) can recognise the recipient&amp;#039;s body cells as foreign and attack them. A distinction is made between acute GvHD (grades 1-4) and chronic GvHD (limited and extensive form). The(...)&lt;\/div&gt;\"  href=\"https:\/\/aa-pnh.org\/en\/glossar\/gvhd\/\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]'  tabindex='0' role='link'>GvHD<\/a> (limited and extensive form). The <a class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;acute&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Sudden onset, rapidly progressing&lt;\/div&gt;\"  href=\"https:\/\/aa-pnh.org\/en\/glossar\/acute\/\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]'  tabindex='0' role='link'>acute<\/a> form is observed in the first 2-3 months after transplantation, later the <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;chronic&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Over a long period of time and persistent&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/chronic\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">chronic<\/a> form. The <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;chronic&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Over a long period of time and persistent&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/chronic\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">chronic<\/a> form often develops from the <a class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;acute&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Sudden onset, rapidly progressing&lt;\/div&gt;\"  href=\"https:\/\/aa-pnh.org\/en\/glossar\/acute\/\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]'  tabindex='0' role='link'>acute<\/a> form, but it can also occur anew. Symptoms can be: reddening of the skin, itching, peeling of the skin, inflammation of the mucous membranes, jaundice, diarrhoea, abdominal pain, organ failure. Immunosuppressive medications are administered for therapy (including <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;ciclosporin&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also known as cyclosporin A, CsA; immunosuppressive medication administered e.g. to treat aplastic anaemia and prevent GvHD disease. In high doses and with long-term administration, its main side effects are hypertension, tremor of the hands and deterioration of kidney function. Blood levels(...)&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/ciclosporin\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">ciclosporin<\/a>, <a class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;ATG&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;ATG; immunosuppressive mixture of antibodies obtained from rabbits or horses. It reduces the number of lymphocytes (lymphocytopenia), mainly by suppressing circulating T-lymphocytes. It is used for instance to treat aplastic anaemia and for the prophylaxis and therapy of GvHD in the context of(...)&lt;\/div&gt;\"  href=\"https:\/\/aa-pnh.org\/en\/glossar\/atg\/\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]'  tabindex='0' role='link'>ATG<\/a>, cortisone).      <\/p>\n","protected":false},"excerpt":{"rendered":"<p><a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;GvHD&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;GvHD; graft versus recipient response. The donor&amp;#039;s immune system transplanted with a foreign donation (e.g. stem cells) can recognise the recipient&amp;#039;s body cells as foreign and attack them. A distinction is made between acute GvHD (grades 1-4) and chronic GvHD (limited and extensive form). The(...)&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/gvhd\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">GvHD<\/a>; graft versus recipient response. The donor&rsquo;s <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;immune system&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Defence system; system that enables the body to fight off infections and to distinguish between its own and foreign tissues. In humans, the immune system consists of specialised proteins (antibodies), immune cells (white blood cells) and immune organs. It is responsible for our body&amp;#039;s defences(...)&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/immune-system\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">immune system<\/a> transplanted with a foreign donation (e.g. stem cells) can recognise the recipient&rsquo;s body cells as foreign and attack them. A distinction is made between <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;acute&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Sudden onset, rapidly progressing&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/acute\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">acute<\/a> <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;GvHD&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;GvHD; graft versus recipient response. The donor&amp;#039;s immune system transplanted with a foreign donation (e.g. stem cells) can recognise the recipient&amp;#039;s body cells as foreign and attack them. A distinction is made between acute GvHD (grades 1-4) and chronic GvHD (limited and extensive form). The(...)&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/gvhd\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">GvHD<\/a> (grades 1-4) and <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;chronic&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Over a long period of time and persistent&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/chronic\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">chronic<\/a> <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;GvHD&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;GvHD; graft versus recipient response. The donor&amp;#039;s immune system transplanted with a foreign donation (e.g. stem cells) can recognise the recipient&amp;#039;s body cells as foreign and attack them. A distinction is made between acute GvHD (grades 1-4) and chronic GvHD (limited and extensive form). The(...)&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/gvhd\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">GvHD<\/a> (limited and extensive form). The&hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"menu_order":0,"template":"","meta":{"footnotes":""},"class_list":["post-3912","glossary","type-glossary","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/glossary\/3912","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/glossary"}],"about":[{"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/types\/glossary"}],"author":[{"embeddable":true,"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/users\/3"}],"version-history":[{"count":0,"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/glossary\/3912\/revisions"}],"wp:attachment":[{"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/media?parent=3912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}