{"id":3642,"date":"2020-11-21T10:09:27","date_gmt":"2020-11-21T09:09:27","guid":{"rendered":"https:\/\/aa-pnh.pe-dev.de\/glossary\/"},"modified":"2022-01-11T19:14:46","modified_gmt":"2022-01-11T18:14:46","slug":"glossary","status":"publish","type":"page","link":"https:\/\/aa-pnh.org\/en\/diseases\/glossary\/","title":{"rendered":"Glossary"},"content":{"rendered":"<div class=\"cm-glossary tiles\"><div class=\"glossary-container \"><input type=\"hidden\" class=\"cmtt-attribute-field\" name=\"glossary_index_style\" value=\"small-tiles\"><div id=\"glossaryList-nav\" class=\"listNav \" role=\"tablist\"><\/div><ul class=\"glossaryList\" role=\"tablist\" id=\"glossaryList\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTermSet\"><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/abdomen\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Abdomen&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Abdomen&lt;\/div&gt;\"><span itemprop=\"name\">Abdomen<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/acute\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;acute&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Sudden onset, rapidly progressing&lt;\/div&gt;\"><span itemprop=\"name\">acute<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/aetiology\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;aetiology&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Cause of a disease&lt;\/div&gt;\"><span itemprop=\"name\">aetiology<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/anaemia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Anaemia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Reduction of red blood cells or their content of (blood pigment); as a result of blood loss, reduced haemoglobin production, reduced blood cell development due to bone marrow diseases, increased blood cell decay due to poisoning and metabolic disorders. Anaemia leads to reduced physical capacity. &lt;\/div&gt;\"><span itemprop=\"name\">Anaemia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/anamnesis\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;anamnesis&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Medical history, development of symptoms&lt;\/div&gt;\"><span itemprop=\"name\">anamnesis<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/angina-pectoris\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Angina pectoris&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Sudden pain\/tightness in the chest, due to a temporary perfusion disorder of the heart associated with coronary artery disease&lt;\/div&gt;\"><span itemprop=\"name\">Angina pectoris<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/antacids\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Antacids&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Medication for neutralising stomach acid&lt;\/div&gt;\"><span itemprop=\"name\">Antacids<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/antibody\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;antibody&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;A protein normally produced by the immune system to defend against a pathogen that has entered the body or another threat; an antibody binds specifically to certain surface structures of the intruder, and triggers a series of further immune reactions that ultimately lead to the killing and(...)&lt;\/div&gt;\"><span itemprop=\"name\">antibody<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/anticoagulation\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Anticoagulation&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Inhibition of blood clotting&lt;\/div&gt;\"><span itemprop=\"name\">Anticoagulation<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/antithymocyte-globulin\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Antithymocyte globulin&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;ATG; immunosuppressive mixture of antibodies obtained from rabbits or horses. It reduces the number of lymphocytes (lymphocytopenia), mainly by suppressing circulating T-lymphocytes. It is used for instance to treat aplastic anaemia and for the prophylaxis and therapy of GvHD in the context of(...)&lt;\/div&gt;\"><span itemprop=\"name\">Antithymocyte globulin<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/apheresis\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;apheresis&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Targeted removal of certain components from the blood using a special apparatus&lt;\/div&gt;\"><span itemprop=\"name\">apheresis<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/aplasia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;aplasia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Condition of the non-functional bone marrow that cannot develop blood cells&lt;\/div&gt;\"><span itemprop=\"name\">aplasia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/aplastic\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;aplastic&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Condition of the non-functional bone marrow that cannot develop blood cells&lt;\/div&gt;\"><span itemprop=\"name\">aplastic<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/arterial-hypertension\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;arterial hypertension&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Arterial hypertension. A clinical picture in which blood pressure in the arterial system is chronically elevated. A systolic blood pressure of more than 140 mmHg and\/or a diastolic blood pressure of more than 90 mmHg is regarded as hypertension. Temporary increases in blood pressure due to(...)&lt;\/div&gt;\"><span itemprop=\"name\">arterial hypertension<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/artery\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;artery&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Blood vessel that carries blood from the heart (exception: coronary arteries) and in which oxygen-rich blood is transported (exception: pulmonary artery)&lt;\/div&gt;\"><span itemprop=\"name\">artery<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/atg\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;ATG&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;ATG; immunosuppressive mixture of antibodies obtained from rabbits or horses. It reduces the number of lymphocytes (lymphocytopenia), mainly by suppressing circulating T-lymphocytes. It is used for instance to treat aplastic anaemia and for the prophylaxis and therapy of GvHD in the context of(...)&lt;\/div&gt;\"><span itemprop=\"name\">ATG<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/bicytopenia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;bicytopenia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Lack of blood cells in two cell lines&lt;\/div&gt;\"><span itemprop=\"name\">bicytopenia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/bnp\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;BNP&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Brain (Ventricular) Natriuretic Peptide; hormone produced in the heart that stimulates the kidneys to excrete sodium and fluids&lt;\/div&gt;\"><span itemprop=\"name\">BNP<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/bone-marrow-aspiration\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;bone marrow aspiration&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Suction of cells and marrow fragments from the bone marrow (usually from the iliac crest) with a hollow needle&lt;\/div&gt;\"><span itemprop=\"name\">bone marrow aspiration<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/bone-marrow-biopsy\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;bone marrow biopsy&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Taking a sample from the bone marrow (usually from the iliac crest) with a tissue punch. This method enables more precise examinations to be carried out than with bone marrow aspiration, since the bone punch cylinder is also obtained. &lt;\/div&gt;\"><span itemprop=\"name\">bone marrow biopsy<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/bone-marrow-hyperplasia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;bone marrow hyperplasia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Bone marrow with too many cells&lt;\/div&gt;\"><span itemprop=\"name\">bone marrow hyperplasia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/bone-marrow-hypoplasia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;bone marrow hypoplasia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Bone marrow with too few cells&lt;\/div&gt;\"><span itemprop=\"name\">bone marrow hypoplasia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/bone-marrow-insufficiency\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;bone marrow insufficiency&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Reduced production of blood cells in the bone marrow&lt;\/div&gt;\"><span itemprop=\"name\">bone marrow insufficiency<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/bone-marrow-puncture\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;bone marrow puncture&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Piercing through the bone into the bone marrow with a hollow needle in order to remove tissue for examination. Usually performed at the iliac crest, it can be used for bone marrow aspiration or bone marrow biopsy.&lt;\/div&gt;\"><span itemprop=\"name\">bone marrow puncture<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/breakthrough-haemolysis\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;breakthrough haemolysis&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Severe haemolysis with severe symptoms; requires treatment&lt;\/div&gt;\"><span itemprop=\"name\">breakthrough haemolysis<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/cellularity\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Cellularity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Cell content of a bone marrow smear&lt;\/div&gt;\"><span itemprop=\"name\">Cellularity<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/chelation-therapy\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;chelation therapy&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Therapy for removal of excess iron, which was stored e.g. by increased transfusions of erythrocyte concentrates&lt;\/div&gt;\"><span itemprop=\"name\">chelation therapy<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/chronic\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;chronic&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Over a long period of time and persistent&lt;\/div&gt;\"><span itemprop=\"name\">chronic<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/ciclosporin\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;ciclosporin&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also known as cyclosporin A, CsA; immunosuppressive medication administered e.g. to treat aplastic anaemia and prevent GvHD disease. In high doses and with long-term administration, its main side effects are hypertension, tremor of the hands and deterioration of kidney function. Blood levels(...)&lt;\/div&gt;\"><span itemprop=\"name\">ciclosporin<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/clone\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;clone&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;A set of cells that all originate from a single parent cell and that all have the same characteristics&lt;\/div&gt;\"><span itemprop=\"name\">clone<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/complement-cascade\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;complement cascade&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Once the complement system has been activated, a cascade-like process takes place for immune defence&lt;\/div&gt;\"><span itemprop=\"name\">complement cascade<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/complement-system\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;complement system&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;A group of plasma proteins for immune defence against microorganisms&lt;\/div&gt;\"><span itemprop=\"name\">complement system<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/complete-remission\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;complete remission&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;CR (complete remission); complete regression of disease symptoms&lt;\/div&gt;\"><span itemprop=\"name\">complete remission<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/conditioning\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;conditioning&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Preparation of a patient for stem cell transplantation in the form of high-dose chemotherapy (high-dose therapy) and, if necessary, whole-body radiation. The recipient&amp;#039;s immune system must be suppressed to such an extent that the donor&amp;#039;s transplant can grow without the risk of rejection. &lt;\/div&gt;\"><span itemprop=\"name\">conditioning<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/contraindication\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;contraindication&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;reason for not carrying out a treatment&lt;\/div&gt;\"><span itemprop=\"name\">contraindication<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/coombs-test\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Coombs test&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Test for the detection of certain antibodies against red blood cells&lt;\/div&gt;\"><span itemprop=\"name\">Coombs test<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/creatinine\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;creatinine&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Nitrogenous metabolic end product that is excreted via the kidneys. An elevated creatinine level in the blood indicates impaired kidney function &lt;\/div&gt;\"><span itemprop=\"name\">creatinine<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/curative\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;curative&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Healing, focused on healing&lt;\/div&gt;\"><span itemprop=\"name\">curative<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/cytogenetic\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;cytogenetic&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;A branch of genetics in which the number and structure of the chromosomes of a dividing cell are examined under a microscope&lt;\/div&gt;\"><span itemprop=\"name\">cytogenetic<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/cytogenetics\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;cytogenetics&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;A branch of genetics in which the number and structure of the chromosomes of a dividing cell are examined under a microscope&lt;\/div&gt;\"><span itemprop=\"name\">cytogenetics<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/cytological\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;cytological&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;The field of general biology that covers the structure and function of cells&lt;\/div&gt;\"><span itemprop=\"name\">cytological<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/cytology\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;cytology&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;The field of general biology that covers the structure and function of cells&lt;\/div&gt;\"><span itemprop=\"name\">cytology<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/cytomegalovirus\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;cytomegalovirus&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;CMV; virus of the herpes group, which can cause serious complications in organ transplanted and immunocompromised patients. The pathogen is widespread in the population. The virus remains in the body for life after initial infection and can be reactivated if the immune system is weakened.   &lt;\/div&gt;\"><span itemprop=\"name\">cytomegalovirus<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/cytopenia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;cytopenia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Reduction in the number of cells in the blood, e.g. erythro-, leuko-, granulo-, lympho- or thrombocytopenia&lt;\/div&gt;\"><span itemprop=\"name\">cytopenia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/dehydration\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;dehydration&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Lack of fluid in the body&lt;\/div&gt;\"><span itemprop=\"name\">dehydration<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/dialysis\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;dialysis&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Blood purification in case of reduced or failed kidney function&lt;\/div&gt;\"><span itemprop=\"name\">dialysis<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/diamond-blackfan-anaemia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Diamond-Blackfan anaemia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;also known as Diamond-Blackfan syndrome, DBA; severe chronic anaemia, usually occurring in early childhood&lt;\/div&gt;\"><span itemprop=\"name\">Diamond-Blackfan anaemia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/differential-blood-count\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;differential blood count&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Routine examination that indicates the cellular composition of the white blood cells (leukocytes) in the blood. The percentages of the individual blood cell types are determined by microscopic counting of a blood smear. The white cells of normal blood include granulocytes (neutrophils,(...)&lt;\/div&gt;\"><span itemprop=\"name\">differential blood count<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/dysphagia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;dysphagia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Problems with swallowing&lt;\/div&gt;\"><span itemprop=\"name\">dysphagia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/dysplasia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;dysplasia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Malformation. Degenerated cells are &amp;quot;dysplastic&amp;quot;, i.e. malformed. Dysplastic cells do not mature (differentiate) normally.  &lt;\/div&gt;\"><span itemprop=\"name\">dysplasia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/dyspnoea\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;dyspnoea&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Shortness of breath&lt;\/div&gt;\"><span itemprop=\"name\">dyspnoea<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/ec-packed-rbcs\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;&amp;#8220;EC&amp;#8221;; packed RBCs&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;packed RBCs; blood with concentrated red blood cells (erythrocytes), which are collected from donors&lt;\/div&gt;\"><span itemprop=\"name\">\"EC\"; packed RBCs<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/enzyme\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;enzyme&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Biocatalyst; a protein that mediates all chemical transformations that occur in living organisms (metabolism). The cells of an organism have a specific enzyme for nearly every chemical reaction. &lt;\/div&gt;\"><span itemprop=\"name\">enzyme<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/epidemiology\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;epidemiology&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Study of the frequency and distribution of diseases in populations&lt;\/div&gt;\"><span itemprop=\"name\">epidemiology<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/erectile-dysfunction\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;erectile dysfunction&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Sexual dysfunction in which the penis does not erect or does not erect for long enough&lt;\/div&gt;\"><span itemprop=\"name\">erectile dysfunction<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/erythrocyte\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;erythrocyte&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Red blood cell; erythrocytes make up the majority of cellular blood components. They are formed in the bone marrow, contain haemoglobin (the red pigment in blood ) and have a life expectancy of about 120 days in healthy people. The haemoglobin content of the blood is an important measurement(...)&lt;\/div&gt;\"><span itemprop=\"name\">erythrocyte<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/erythrocytes\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Erythrocytes&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Red blood cell; erythrocytes make up the majority of cellular blood components. They are formed in the bone marrow, contain haemoglobin (the red pigment in blood ) and have a life expectancy of about 120 days in healthy people. The haemoglobin content of the blood is an important measurement(...)&lt;\/div&gt;\"><span itemprop=\"name\">Erythrocytes<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/erythrocytopenia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;erythrocytopenia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Red blood cell (erythrocyte) deficiency&lt;\/div&gt;\"><span itemprop=\"name\">erythrocytopenia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/erythropoetin\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;erythropoetin&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Epo; a hormone formed in the kidney, which can also be produced by genetic engineering and is available as a medication that stimulates the formation of red blood cells. This substance is administered in certain forms of blood deficiency.  &lt;\/div&gt;\"><span itemprop=\"name\">erythropoetin<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/extravascular\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;extravascular&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Outside the blood vessels&lt;\/div&gt;\"><span itemprop=\"name\">extravascular<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/extravascular-haemolysis\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;extravascular haemolysis&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Breakdown of red blood cells outside blood vessels&lt;\/div&gt;\"><span itemprop=\"name\">extravascular haemolysis<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/fanconi-anaemia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Fanconi anaemia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Hereditary disease in which red and white blood cells are produced in a reduced quantity and broken down more quickly&lt;\/div&gt;\"><span itemprop=\"name\">Fanconi anaemia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/fatigue\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;fatigue&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Severe tiredness, exhaustion or increased need for rest; a symptom that often accompanies various chronic diseasesitet&lt;\/div&gt;\"><span itemprop=\"name\">fatigue<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/ferritin\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;ferritin&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Protein that stores iron; if ECs are given frequently, the ferritin level should be monitored in case chelation therapy becomes necessary.&lt;\/div&gt;\"><span itemprop=\"name\">ferritin<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/fibrosis\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;fibrosis&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Abnormal proliferation of connective tissue in the bone marrow or an organ&lt;\/div&gt;\"><span itemprop=\"name\">fibrosis<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/first-line-therapy\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;first-line therapy&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;First-choice therapy, may be described in a guideline as the most suitable treatment&lt;\/div&gt;\"><span itemprop=\"name\">first-line therapy<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/flow-cytometry\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;flow cytometry&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Measurement method that enables the analysis of cells that each pass an electric voltage or a light beam at high speed. Depending on the shape, structure and\/or colouring of the cells, different effects are produced, from which the properties of the cells can be recorded. Used in the diagnosis(...)&lt;\/div&gt;\"><span itemprop=\"name\">flow cytometry<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/g-csf\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;G-CSF&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;G-CSF; genetically engineered drug that promotes the development of granulocytes and leads to washout of stem cells from the bone marrow into the blood. It is tolerated quite well, but may cause temporary fever and limb pain in a small proportion of patients. &lt;\/div&gt;\"><span itemprop=\"name\">G-CSF<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/gingival-hyperplasia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;gingival hyperplasia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Overproliferation of the gums; may occur with administration of ciclosporin&lt;\/div&gt;\"><span itemprop=\"name\">gingival hyperplasia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/granulocyte\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;granulocyte&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Subgroup of white blood cells; they destroy invading bacteria that can cause diseases &lt;\/div&gt;\"><span itemprop=\"name\">granulocyte<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/granulocyte-colony-stimulating-factor\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;granulocyte colony stimulating factor&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;G-CSF; genetically engineered drug that promotes the development of granulocytes and leads to washout of stem cells from the bone marrow into the blood. It is tolerated quite well, but may cause temporary fever and limb pain in a small proportion of patients.  &lt;\/div&gt;\"><span itemprop=\"name\">granulocyte colony stimulating factor<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/granulocytes\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;granulocytes&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;subgroup of white blood cells They destroy invading bacteria that can cause diseases. &lt;\/div&gt;\"><span itemprop=\"name\">granulocytes<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/gvhd\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;GvHD&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;GvHD; graft versus recipient response. The donor&amp;#039;s immune system transplanted with a foreign donation (e.g. stem cells) can recognise the recipient&amp;#039;s body cells as foreign and attack them. A distinction is made between acute GvHD (grades 1-4) and chronic GvHD (limited and extensive form). The(...)&lt;\/div&gt;\"><span itemprop=\"name\">GvHD<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/haematoma\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;haematoma&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Bruise&lt;\/div&gt;\"><span itemprop=\"name\">haematoma<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/haematopoesis\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;haematopoesis&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Blood development&lt;\/div&gt;\"><span itemprop=\"name\">haematopoesis<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/haemoglobin\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;haemoglobin&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Hb; red blood cell pigment consisting of haem (an iron-containing component) and globin (a protein). Binds, transports and releases oxygen and carbon dioxide. Reference values: women 12-16 g\/dl or 7.5-9.9 mmol\/l, men 14-18 g\/dl or 8.7-11.2 mmol\/l &lt;\/div&gt;\"><span itemprop=\"name\">haemoglobin<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/haemoglobinuria\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;haemoglobinuria&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Excretion of haemoglobin in the urine, resulting in darkened urine; may lead to acute kidney failure if severe &lt;\/div&gt;\"><span itemprop=\"name\">haemoglobinuria<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/haemolysis\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;haemolysis&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Breakdown of red blood cells&lt;\/div&gt;\"><span itemprop=\"name\">haemolysis<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/haemolytic\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;haemolytic&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Breakdown of red blood cells&lt;\/div&gt;\"><span itemprop=\"name\">haemolytic<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/haemolytic-anaemia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;haemolytic anaemia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Form of anaemia caused by increased breakdown or decay of red blood cells. This leads to shortening of the life span of the erythrocytes. Depending on the site affected, a distinction can be made between haemolysis inside the blood vessels (intravascular) and outside the blood vessels(...)&lt;\/div&gt;\"><span itemprop=\"name\">haemolytic anaemia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/haemolytic-crisis\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;haemolytic crisis&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Sudden massive haemolysis. Possible signs are fever, chills, circulatory problems up to and including collapse, abdominal pain, backache, headache, dark urine and later yellowing of the skin. &lt;\/div&gt;\"><span itemprop=\"name\">haemolytic crisis<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/hb-hgb\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Hb; HGB&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;haemoglobin; red blood cell pigment consisting of haem (an iron-containing component) and globin (a protein). Binds, transports and releases oxygen and carbon dioxide. Reference values: women 12-16 g\/dl or 7.5-9.9 mmol\/l, men 14-18 g\/dl or 8.7-11.2 mmol\/l&lt;\/div&gt;\"><span itemprop=\"name\">Hb; HGB<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/histology\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;histology&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Science of tissues: the branch of medicine that involves tissues at the microscopic level&lt;\/div&gt;\"><span itemprop=\"name\">histology<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/hla\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;HLA&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;human leukocyte antigen; protein structure on the surface of most body cells. They help the immune system to differentiate between &amp;quot;self&amp;quot; and &amp;quot;foreign&amp;quot; material. &lt;\/div&gt;\"><span itemprop=\"name\">HLA<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/hla-compatibility\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;HLA compatibility&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Since an unrelated donor can never be completely &amp;quot;identical&amp;quot;, we refer to HLA compatibility in this context&lt;\/div&gt;\"><span itemprop=\"name\">HLA compatibility<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/hla-compatible\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;HLA compatible&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Since an unrelated donor can never be completely &amp;quot;identical&amp;quot;, we refer to HLA compatibility in this context&lt;\/div&gt;\"><span itemprop=\"name\">HLA compatible<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/hla-identical\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;HLA identical&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Complete identity of the 10 most important HLA antigens (A, B, C, DRB1, DQB1)&lt;\/div&gt;\"><span itemprop=\"name\">HLA identical<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/hla-identity\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;HLA identity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Complete identity of the 10 most important HLA antigens (A, B, C, DRB1, DQB1)&lt;\/div&gt;\"><span itemprop=\"name\">HLA identity<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/hla-system\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;HLA system&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;An important regulatory system for the organism&amp;#039;s immune defences. HLA typing is extremely important in preparation for allogenic transplantation. The more similar the HLA systems of donor and recipient, the lower the risk of transplant rejection and GvHD and the greater the chance of(...)&lt;\/div&gt;\"><span itemprop=\"name\">HLA system<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/hla-typing\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;HLA typing&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Examination of HLA characteristics A, B, C, DRB1 and DQB1 for stem cell transplantation&lt;\/div&gt;\"><span itemprop=\"name\">HLA typing<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/human-leukocyte-antigene\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Human Leukocyte Antigene&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;HLA system; human leucocyte antigen; protein structure on the surface of most body cells. They help the immune system to differentiate between &amp;quot;self&amp;quot; and &amp;quot;foreign&amp;quot; material.  &lt;\/div&gt;\"><span itemprop=\"name\">Human Leukocyte Antigene<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/hydration\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;hydration&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Therapeutic replacement of body fluid deficiency, e.g. in cases of high blood loss or massive diarrhoea. In order to compensate quickly for fluid loss, supplementation is usually carried out as an infusion. &lt;\/div&gt;\"><span itemprop=\"name\">hydration<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/hypoplasia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;hypoplasia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Mal\/underdevelopment of the bone marrow or an organ&lt;\/div&gt;\"><span itemprop=\"name\">hypoplasia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/hypoplastic\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;hypoplastic&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Mal\/underdevelopment of the bone marrow or an organ&lt;\/div&gt;\"><span itemprop=\"name\">hypoplastic<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/icterus\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;icterus&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;jaundice; yellowish discolouration of the skin and mucous membranes&lt;\/div&gt;\"><span itemprop=\"name\">icterus<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/idiopathic\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;idiopathic&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Without identifiable cause&lt;\/div&gt;\"><span itemprop=\"name\">idiopathic<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/immune-system\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;immune system&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Defence system; system that enables the body to fight off infections and to distinguish between its own and foreign tissues. In humans, the immune system consists of specialised proteins (antibodies), immune cells (white blood cells) and immune organs. It is responsible for our body&amp;#039;s defences(...)&lt;\/div&gt;\"><span itemprop=\"name\">immune system<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/immunosuppression\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;immunosuppression&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Suppression of the immune system&lt;\/div&gt;\"><span itemprop=\"name\">immunosuppression<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/immunosuppressive\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;immunosuppressive&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Suppression of the immune system&lt;\/div&gt;\"><span itemprop=\"name\">immunosuppressive<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/incidence\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;incidence&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Frequency of new cases per 100,000 inhabitants per year&lt;\/div&gt;\"><span itemprop=\"name\">incidence<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/indication\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;indication&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Reason to perform a medical procedure&lt;\/div&gt;\"><span itemprop=\"name\">indication<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/infusion\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;infusion&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Injection of a liquid into a vein&lt;\/div&gt;\"><span itemprop=\"name\">infusion<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/intravascular\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;intravascular&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Inside blood vessels&lt;\/div&gt;\"><span itemprop=\"name\">intravascular<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/intravascular-haemolysis\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;intravascular haemolysis&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Breakdown of red blood cells inside the blood vessels&lt;\/div&gt;\"><span itemprop=\"name\">intravascular haemolysis<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/intravenous\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;intravenous&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;i.v.; injection of a medication into a vein&lt;\/div&gt;\"><span itemprop=\"name\">intravenous<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/jamshidi-needle\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Jamshidi needle&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Punch needle for bone marrow biopsy&lt;\/div&gt;\"><span itemprop=\"name\">Jamshidi needle<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/lactate-dehydrogenase\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Lactate dehydrogenase&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;LDH; marker in the blood indicating cell damage&lt;\/div&gt;\"><span itemprop=\"name\">Lactate dehydrogenase<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/ldh\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;LDH&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;lactate dehydrogenase; marker in the blood indicating cell damage&lt;\/div&gt;\"><span itemprop=\"name\">LDH<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/leukocyte\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;leukocyte&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;White blood cell. Cells with a wide variety of forms and functions. The leukocytes are responsible for defending against pathogens and removing debris due to decaying cells.  &lt;\/div&gt;\"><span itemprop=\"name\">leukocyte<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/leukocytes\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;leukocytes&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;White blood cell. Cells with a wide variety of forms and functions. The leukocytes are responsible for defending against pathogens and removing debris due to decaying cells.  &lt;\/div&gt;\"><span itemprop=\"name\">leukocytes<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/leukocytopenia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;leukocytopenia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Deficiency of white blood cells&lt;\/div&gt;\"><span itemprop=\"name\">leukocytopenia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/lymphocyte\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;lymphocyte&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Subgroup of white blood cells that play a role in the defence against diseases and foreign substances&lt;\/div&gt;\"><span itemprop=\"name\">lymphocyte<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/lymphocytes\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;lymphocytes&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Subgroup of white blood cells that play a role in the defence against diseases and foreign substances&lt;\/div&gt;\"><span itemprop=\"name\">lymphocytes<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/malignant\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;malignant&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Characterises abnormal cell growth&lt;\/div&gt;\"><span itemprop=\"name\">malignant<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/meningococci\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;meningococci&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Bacteria that colonise the nasopharynx and can lead to serious diseases, e.g. meningitis. They are transmitted from person to person by droplet infection, for example when coughing, sneezing or kissing. There are 13 known meningococcal groups (A, B, C, D, 29E, H, I, K, L, W-135, X, Y and Z).(...)&lt;\/div&gt;\"><span itemprop=\"name\">meningococci<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/monotherapy\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;monotherapy&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Medication with only one active substance&lt;\/div&gt;\"><span itemprop=\"name\">monotherapy<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/morbidity\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;morbidity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Frequency of illness; complaints and complications caused by an illness or during therapy&lt;\/div&gt;\"><span itemprop=\"name\">morbidity<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/mortality\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;mortality&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Death rate&lt;\/div&gt;\"><span itemprop=\"name\">mortality<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/mutation\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;mutation&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Alteration of genetic material (gene)&lt;\/div&gt;\"><span itemprop=\"name\">mutation<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/neutropenia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;neutropenia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Deficiency of neutrophils&lt;\/div&gt;\"><span itemprop=\"name\">neutropenia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/neutrophil\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;neutrophil&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Subgroup of granulocytes with an important role in defending against bacterial and fungal infections&lt;\/div&gt;\"><span itemprop=\"name\">neutrophil<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/neutrophils\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;neutrophils&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Subgroup of granulocytes with an important role in defending against bacterial and fungal infections&lt;\/div&gt;\"><span itemprop=\"name\">neutrophils<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/packed-rbcs\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;packed RBCs&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;packed RBCs; blood with concentrated red blood cells (erythrocytes), which are collected from donors &lt;\/div&gt;\"><span itemprop=\"name\">packed RBCs<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/pancytopenia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;pancytopenia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Tricytopenia; deficiency of blood cells of all three cell lines (erythrocytes, leukocytes, platelets)&lt;\/div&gt;\"><span itemprop=\"name\">pancytopenia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/partial-remission\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;partial remission&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;PR (partial remission); decrease in disease symptoms by at least 50%&lt;\/div&gt;\"><span itemprop=\"name\">partial remission<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/pathogenesis\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;pathogenesis&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Origin and development of a disease&lt;\/div&gt;\"><span itemprop=\"name\">pathogenesis<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/pbsc\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;PBSC&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;peripheral blood stem cells&lt;\/div&gt;\"><span itemprop=\"name\">PBSC<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/pc\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;&amp;#8220;PC&amp;#8221;&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;&amp;quot;PC&amp;quot;; blood with concentrated platelets from a blood donor&lt;\/div&gt;\"><span itemprop=\"name\">\"PC\"<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/peripheral\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;peripheral&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Area outside a centre or origin; peripheral blood is blood in the peripheral circulation&lt;\/div&gt;\"><span itemprop=\"name\">peripheral<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/periphery\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;periphery&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Area outside a centre or origin; peripheral blood is blood in the peripheral circulation&lt;\/div&gt;\"><span itemprop=\"name\">periphery<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/petechia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;petechia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;pl. petechiae; tiny, localised, red spot on the skin caused by bleeding from small blood vessels close to the skin. Petechiae are often caused by a lack of platelets. &lt;\/div&gt;\"><span itemprop=\"name\">petechia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/pnh-clone\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;PNH clone&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;All blood cells affected by the mutation typical of PNH; the size of the PNH clone is a measure of the severity of the disease&lt;\/div&gt;\"><span itemprop=\"name\">PNH clone<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/progression\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;progression&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Progression of a disease&lt;\/div&gt;\"><span itemprop=\"name\">progression<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/prophylactic\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;prophylactic&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Prevention or precaution&lt;\/div&gt;\"><span itemprop=\"name\">prophylactic<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/prophylaxis\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;prophylaxis&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Prevention or precaution&lt;\/div&gt;\"><span itemprop=\"name\">prophylaxis<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/protein\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;protein&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Macromolecule consisting of one or more long chains of amino acids&lt;\/div&gt;\"><span itemprop=\"name\">protein<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/pulmonary-hypertension\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;pulmonary hypertension&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Pulmonary hypertension. A disease characterised by an increase in blood pressure in the pulmonary circulation and often by an increasing rise in vascular resistance in the pulmonary arteries. Patients suffer from severely restricted physical performance, circulatory disorders and fatigue. &lt;\/div&gt;\"><span itemprop=\"name\">pulmonary hypertension<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/refractory\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;refractory&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;A disease is refractory if it does not respond to therapy.&lt;\/div&gt;\"><span itemprop=\"name\">refractory<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/relapse\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;relapse&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Recurrence of disease after a period without symptoms or complaints&lt;\/div&gt;\"><span itemprop=\"name\">relapse<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/remission\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;remission&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Temporary alleviation or cessation of the symptoms of a disease, but which may not result in a cure. A distinction is made between complete and partial remission. &lt;\/div&gt;\"><span itemprop=\"name\">remission<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/renal\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;renal&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Involving the kidney&lt;\/div&gt;\"><span itemprop=\"name\">renal<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/reticulocyte\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;reticulocyte&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Young, immature red blood cell; precursor of erythrocyte&lt;\/div&gt;\"><span itemprop=\"name\">reticulocyte<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/sclera\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;sclera&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;White outer layer of the eyeball that surrounds and protects it.&lt;\/div&gt;\"><span itemprop=\"name\">sclera<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/second-line-treatment\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;second-line treatment&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Treatment according to a guideline after failure (or intolerance) of first-line treatment&lt;\/div&gt;\"><span itemprop=\"name\">second-line treatment<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/somatic\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;somatic&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Involving the body&lt;\/div&gt;\"><span itemprop=\"name\">somatic<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/sonography\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;sonography&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Ultrasound; imaging method of examination&lt;\/div&gt;\"><span itemprop=\"name\">sonography<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/splenomegaly\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;splenomegaly&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Enlargement of the spleen e.g. in leukaemia and lymphoma, infection with bacteria or viruses, rheumatic disease, (lysosomal) storage disease. An enlarged spleen may store blood cells and cause a general lack of blood cells (pancytopenia). The underlying disease needs to be treated, and in rare(...)&lt;\/div&gt;\"><span itemprop=\"name\">splenomegaly<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/supportive\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;supportive&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;help other than with a disease-specific drug&lt;\/div&gt;\"><span itemprop=\"name\">supportive<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/tachycardia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;tachycardia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Accelerated heartbeat (over 100 beats per minute in adults)&lt;\/div&gt;\"><span itemprop=\"name\">tachycardia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/telomere\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;telomere&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;End of chromosomes that shorten with each cell division&lt;\/div&gt;\"><span itemprop=\"name\">telomere<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/telomeropathy\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;telomeropathy&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Disease in which telomere shortening is exacerbated&lt;\/div&gt;\"><span itemprop=\"name\">telomeropathy<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/thorax\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;thorax&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Chest, thorax&lt;\/div&gt;\"><span itemprop=\"name\">thorax<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/thrombocyte\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;thrombocyte&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Platelet; smallest form of blood cells, whose main task is to maintain blood clotting&lt;\/div&gt;\"><span itemprop=\"name\">thrombocyte<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/thrombocyte-concentrate\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;thrombocyte concentrate&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;blood with concentrated platelets from a blood donor &lt;\/div&gt;\"><span itemprop=\"name\">thrombocyte concentrate<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/thrombocytes\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;thrombocytes&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Smallest form of blood cells, whose main task is to maintain blood clotting&lt;\/div&gt;\"><span itemprop=\"name\">thrombocytes<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/thrombocytopenia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;thrombocytopenia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Platelet deficiency&lt;\/div&gt;\"><span itemprop=\"name\">thrombocytopenia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/thromboembolic\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;thromboembolic&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;A blood clot that is carried into the bloodstream and leads to closure of the affected blood vessel, which is then unable to supply the corresponding organs &lt;\/div&gt;\"><span itemprop=\"name\">thromboembolic<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/thromboembolism\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;thromboembolism&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;A blood clot that is carried into the bloodstream and leads to closure of the affected blood vessel, which is then unable to supply the corresponding organs &lt;\/div&gt;\"><span itemprop=\"name\">thromboembolism<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/thrombophila\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;thrombophila&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Condition in which an imbalance of clotting factors increases the risk of thrombosis (developing blood clots)&lt;\/div&gt;\"><span itemprop=\"name\">thrombophila<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/thrombopoetin\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;thrombopoetin&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Hormone that stimulates platelet formation&lt;\/div&gt;\"><span itemprop=\"name\">thrombopoetin<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/thrombosis\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;thrombosis&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Vascular disease in which a clot forms in a blood vessel; can occur in any vessel, most commonly in veins, especially in the deep veins of the legs&lt;\/div&gt;\"><span itemprop=\"name\">thrombosis<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/toxic\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;toxic&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;toxic&lt;\/div&gt;\"><span itemprop=\"name\">toxic<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/toxicity\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;toxicity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Toxicity&lt;\/div&gt;\"><span itemprop=\"name\">toxicity<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/transfuse\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;transfuse&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Transfer of blood or blood components&lt;\/div&gt;\"><span itemprop=\"name\">transfuse<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/transfusion\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;transfusion&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Transfer of blood or blood components&lt;\/div&gt;\"><span itemprop=\"name\">transfusion<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/tremor\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;tremor&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Shaking&lt;\/div&gt;\"><span itemprop=\"name\">tremor<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/tricytopenia\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;tricytopenia&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Pancytopenia; deficiency of blood cells of all three cell lines (erythrocytes, leukocytes, platelets)&lt;\/div&gt;\"><span itemprop=\"name\">tricytopenia<\/span><\/a><\/li><li class=\"\" itemscope itemtype=\"https:\/\/schema.org\/DefinedTerm\"><a href=\"https:\/\/aa-pnh.org\/en\/glossar\/vein\/\" role=\"term\" class=\"glossaryLinkMain \" style=\"\" itemprop=\"url\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;vein&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Blood vessel that leads to the heart and transports oxygen-poor blood (exception: pulmonary vein)&lt;\/div&gt;\"><span itemprop=\"name\">vein<\/span><\/a><\/li><\/ul><\/div><div class=\"clear clearfix cmtt-clearfix\"><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":7,"featured_media":0,"parent":3689,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3642","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/pages\/3642","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/comments?post=3642"}],"version-history":[{"count":0,"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/pages\/3642\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/pages\/3689"}],"wp:attachment":[{"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/media?parent=3642"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}