{"id":3633,"date":"2021-02-02T20:43:35","date_gmt":"2021-02-02T19:43:35","guid":{"rendered":"https:\/\/aa-pnh.pe-dev.de\/recommendations-of-the-ulm-university-hospital-on-covid-19-vaccination-in-aa-pnh\/"},"modified":"2021-12-08T10:18:25","modified_gmt":"2021-12-08T09:18:25","slug":"recommendations-of-the-ulm-university-hospital-on-covid-19-vaccination-in-aa-pnh","status":"publish","type":"post","link":"https:\/\/aa-pnh.org\/en\/recommendations-of-the-ulm-university-hospital-on-covid-19-vaccination-in-aa-pnh\/","title":{"rendered":"RECOMMENDATIONS OF THE ULM UNIVERSITY HOSPITAL ON COVID-19 VACCINATION IN AA\/PNH"},"content":{"rendered":"<p>A few weeks ago, vaccinations against the SARS-CoV-2 virus began in Germany. As announced in our February virtual group meeting, the Ulm University Hospital, as one of the most important AA\/PNH centres in Germany, has now published a <a href=\"https:\/\/aa-pnh.org\/wp-content\/uploads\/2021\/02\/UK-Ulm-Empfehlungen-COVID-19-Impfung-202101.pdf\" rel=\"noopener noreferrer\" target=\"_blank\">recommendation letter (German)<\/a> on this topic. If you need assistance with details contained in the recommendation letter please email us at info(at)aa-pnh.org or give us a call: +49 30 549094080. <\/p>\n<p>We briefly summarise the most important contents for you below:<!--more--><\/p>\n<p>The Ulm University Hospital&rsquo;s vaccination advice letter for AA\/PNH patients is based on the current recommendations of the St&auml;ndige Impfkommission (STIKO) of the Robert Koch Institute, previous studies on the approved vaccines, and the Ulm AA\/PNH Centre&rsquo;s experience with COVID-19 vaccinations.<\/p>\n<p>I. For PNH patients receiving eculizumab\/ravulizumab therapy, the COVID-19 vaccination does not represent an increased risk compared to other vaccinations and is therefore recommended. The first vaccination should be given as close after eculizumab\/ravulizumab administration as possible. After the vaccination, some blood values (<a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;haemolysis&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Breakdown of red blood cells&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/haemolysis\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">haemolysis<\/a> parameters and <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;antibody&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;A protein normally produced by the immune system to defend against a pathogen that has entered the body or another threat; an antibody binds specifically to certain surface structures of the intruder, and triggers a series of further immune reactions that ultimately lead to the killing and(...)&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/antibody\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">antibody<\/a> titres) should be checked in order to allow swift reaction in the event of a <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;haemolytic crisis&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Sudden massive haemolysis. Possible signs are fever, chills, circulatory problems up to and including collapse, abdominal pain, backache, headache, dark urine and later yellowing of the skin. &lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/haemolytic-crisis\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">haemolytic crisis<\/a> and to check the success of the vaccination.<\/p>\n<p>II. For PNH patients without eculizumab\/ravulizumab therapy, recommendations from the Ulm University Hospital are still being developed.<\/p>\n<p>III. For AA patients, COVID-19 vaccination carries a lower risk than COVID-19 infection &ndash; however, an individual risk assessment (current therapy, immune status, etc.) must be carried out before vaccination. Vaccination is also recommended for patients on <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;ciclosporin&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also known as cyclosporin A, CsA; immunosuppressive medication administered e.g. to treat aplastic anaemia and prevent GvHD disease. In high doses and with long-term administration, its main side effects are hypertension, tremor of the hands and deterioration of kidney function. Blood levels(...)&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/ciclosporin\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">ciclosporin<\/a> therapy.<\/p>\n<p>Vaccination is also recommended for patients on <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;ciclosporin&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also known as cyclosporin A, CsA; immunosuppressive medication administered e.g. to treat aplastic anaemia and prevent GvHD disease. In high doses and with long-term administration, its main side effects are hypertension, tremor of the hands and deterioration of kidney function. Blood levels(...)&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/ciclosporin\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">ciclosporin<\/a> therapy. Based on previous surveys on COVID-19 <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;mortality&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Death rate&lt;\/div&gt;\" href=\"https:\/\/aa-pnh.org\/en\/glossar\/mortality\/\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">mortality<\/a>, the STIKO sees the greatest risk for people of advanced age. Accordingly, only this group has been vaccinated with the highest priority so far (CoronaImpfV &sect;3). <\/p>\n<p>We will notify you about further changes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A few weeks ago, vaccinations against the SARS-CoV-2 virus began in Germany. As announced in our February virtual group meeting, the Ulm University Hospital, as one of the most important AA\/PNH centres in Germany, has now published a recommendation letter (German) on this topic. If&hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"gallery","meta":{"footnotes":""},"categories":[82,86,87,81,100],"tags":[99,89,85,83,102],"class_list":["post-3633","post","type-post","status-publish","format-gallery","hentry","category-clinical-studies","category-illness","category-infection","category-medication","category-vaccination","tag-aplastic-anemia","tag-infections","tag-pnh-en","tag-studies","tag-vaccination","post_format-post-format-gallery"],"_links":{"self":[{"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/posts\/3633","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/comments?post=3633"}],"version-history":[{"count":0,"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/posts\/3633\/revisions"}],"wp:attachment":[{"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/media?parent=3633"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/categories?post=3633"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/aa-pnh.org\/en\/wp-json\/wp\/v2\/tags?post=3633"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}